Andriol Testocaps

54,00

Artikelnummer: 638a Kategorien: , Schlüsselwort:

Beschreibung

Pharmachologic effect

Testosterone is an endogenous hormone necessary for the normal development of male genital organs and secondary sexual characteristics, to maintain normal function of the testicles, the prostate gland and seminal vesicles, maintaining libido and potency. The use of the drug for the treatment of hypogonadism in men leads to a clinically significant increase in the concentration in the plasma of testosterone, dihydrotestosterone and androstenedione and a decrease in globulin binding sex hormones (SHGG). In men with primary (hypergonadotropic) hypogonadism, the use of the drug leads to normalization of gonadotropin concentration.

Pharmacokinetics

After ingestion, a large part of the testosterone undecanoate together with the lipophilic solvent is absorbed into the small intestine and enters the lymphatic system, thus avoiding the primary passage through the liver. With the absorption of Testosteron Undecanoat is partially reduced with the formation of dihydrotestosterone undecanoate. From the lymphatic system, he enters the plasma. In the plasma and tissues, as a result of the hydrolysis of testosterone undecanoate and ditrotestosterone undecanoate, the natural male sex hormones testosterone and dihydrotestosterone are released.
A single administration of 80-160 mg of Andriol TC leads to a clinically significant increase in the total plasma concentration of testosterone, Cmax is approximately 40 nmol / L and is achieved 4-5 hours after administration. The increased concentration of testosterone is retained, but at least for 8 hours. It is excreted mainly with urine in the form of conjugates (etiocholanolone and androsterone).

Dosage

The dose is selected individually depending on the clinical effect.
As a rule, the initial dose is 120-160 mg / day for 2-3 weeks, maintaining a dose of 40-120 mg / day.
The drug should be taken with food, washed down with a small amount of water. Capsules should be swallowed whole, not liquid. It is advisable to take half the dose in the morning, and the second half in the evening. If an uneven number of capsules is taken, a higher dose should be taken in the morning.

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